The rise of neural stem cells: From development to disease
The brain is a remarkably complex organ that arises during development from neural stem cells. Neural stem cells undergo self-renewing divisions to first expand their pool and then differentiate, either via intermediate progenitors or directly into neurons to form the developing brain. Glial cells, namely astrocytes and oligodendrocytes, are generated later in development. This sequential development is the result of precisely timed patterning and signaling that underlie proper brain formation.
The brain is a remarkably complex organ that arises during development from neural stem cells. Neural stem cells undergo self-renewing divisions to first expand their pool and then differentiate, either via intermediate progenitors or directly into neurons to form the developing brain. Glial cells, namely astrocytes and oligodendrocytes, are generated later in development. This sequential development is the result of precisely timed patterning and signaling that underlie proper brain formation.
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