Mitochondria regulate the cell fate decisions of megakaryocyte-erythroid progenitors
Motohashi and colleagues have found that mitochondrial activity regulates bifurcating fate decision by megakaryocyte-erythroid progenitors (MEPs). The mitochondrial function supported by CARS2-mediated production of cysteine persulfide is essential for erythroid differentiation of MEPs. MEPs containing more mitochondria preferentially differentiate into erythroblasts. These findings reveal critical contributions of mitochondria to cell differentiation, acting as a “mitochondrial navigation” for lineage commitment.
Motohashi and colleagues have found that mitochondrial activity regulates bifurcating fate decision by megakaryocyte-erythroid progenitors (MEPs). The mitochondrial function supported by CARS2-mediated production of cysteine persulfide is essential for erythroid differentiation of MEPs. MEPs containing more mitochondria preferentially differentiate into erythroblasts. These findings reveal critical contributions of mitochondria to cell differentiation, acting as a “mitochondrial navigation” for lineage commitment.
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