Hypersynchronous iPSC-derived SHANK2 neuronal networks are rescued by mGluR5 agonism
McCready and colleagues use isogenic induced pluripotent stem cell lines to show that SHANK2 null neurons associated with autism spectrum disorder form hyperactive networks. These networks are hypersynchronous and lack reverberating super bursts (RSBs) that are readily detected in neurotypical control networks. Treatment of SHANK2 neurons with an mGluR agonist rescues RSBs and hypersynchrony.
McCready and colleagues use isogenic induced pluripotent stem cell lines to show that SHANK2 null neurons associated with autism spectrum disorder form hyperactive networks. These networks are hypersynchronous and lack reverberating super bursts (RSBs) that are readily detected in neurotypical control networks. Treatment of SHANK2 neurons with an mGluR agonist rescues RSBs and hypersynchrony.
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