High-dose radiation preferentially induces the clonal expansion of hematopoietic progenitor cells over mature T and B cells in mouse bone marrow
Yoshida and colleagues show that radiation induces clonal hematopoiesis more preferentially derived from hematopoietic progenitors than mature T and B cells, by examining somatic mutations and TCR and BCR sequences in 3-Gy irradiated mice. Their results suggest the importance of the types of clonally expanded blood cell populations for assessing the risk of various diseases due to radiation exposure.
Yoshida and colleagues show that radiation induces clonal hematopoiesis more preferentially derived from hematopoietic progenitors than mature T and B cells, by examining somatic mutations and TCR and BCR sequences in 3-Gy irradiated mice. Their results suggest the importance of the types of clonally expanded blood cell populations for assessing the risk of various diseases due to radiation exposure.
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