Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion
Thanou et al. show that intracerebroventricular AraC injection disrupts SVZ cytoarchitecture and myelin integrity, inducing acute neuroinflammation with peripheral immune cell infiltration. They further demonstrate ectopic recruitment of neuroblasts to the striatum and nucleus accumbens, with selective accumulation of neuroblasts within striatal myelin bundles, uncovering alternative neuroblast migration pathways likely linked to myelin dysregulation.
Thanou et al. show that intracerebroventricular AraC injection disrupts SVZ cytoarchitecture and myelin integrity, inducing acute neuroinflammation with peripheral immune cell infiltration. They further demonstrate ectopic recruitment of neuroblasts to the striatum and nucleus accumbens, with selective accumulation of neuroblasts within striatal myelin bundles, uncovering alternative neuroblast migration pathways likely linked to myelin dysregulation.
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