Distinct roles of TET-mediated cytosine oxidation in neural stem cell fate decisions
Ten-eleven translocation (TET) enzymes regulate neural stem cell development via distinct cytosine oxidation steps. This study, by Ebert et al. reveals that hydroxymethylation is crucial for neurogenesis, while formylation and carboxylation drive gliogenesis, offering insights into TET biology and therapeutic potential in neurodevelopmental and neurodegenerative disorders.
Ten-eleven translocation (TET) enzymes regulate neural stem cell development via distinct cytosine oxidation steps. This study, by Ebert et al. reveals that hydroxymethylation is crucial for neurogenesis, while formylation and carboxylation drive gliogenesis, offering insights into TET biology and therapeutic potential in neurodevelopmental and neurodegenerative disorders.
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